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''Listeria monocytogenes'' is a gram positive bacterium and causes many food-borne infections such as Listeriosis. This bacteria is ubiquitous in the environment where it can act as either a saprophyte when free living within the environment or as a pathogen when entering a host organism. Many non-coding RNAs have been identified within the bacteria genome where several of these have been classified as novel non-coding RNAs and may contribute to pathogenesis. Tiling arrays and mutagenesis identified many non-coding RNAs within the ''L. monocytogenes'' genome and the location of these non-coding RNAs within the bacterial genome was confirmed by RACE (rapid amplification of cDNA ends) analysis. These studies showed that the expression of many non-coding RNAs was dependent on the environment and that several of these non-coding RNAs act as cis-regulatory elements. Comparisons between previously characterized non-coding RNAs and those present in the ''L. monocyotogenes'' genome identified 50 novel non-coding RNAs in ''L. monocyotogenes''. An additional comparative study between the pathogenic ''L. monocytogenes'' strain and the non pathogenic ''L. innocua'' strain identified several non-coding RNAs that are only present within ''L. monocytogenes'' which suggests that these ncRNAs may have a role in pathogenesis. The tables below summarizes the location, flanking genes and also the characteristics of the novel small non-coding RNAs identified and the previously characterized non-coding RNAs present in ''L. monocytogenes'' Novel Non-coding RNAs aArrows indicate the sense of the gene on the genome. Bold arrows indicate gene absent from ''L. innocua''. Listeria monocytogenes EGD-e strain was used in these studies EMBL accession AL591824.1 Characterised non-coding RNAs ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Listeria monocytogenes non-coding RNA」の詳細全文を読む スポンサード リンク
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